C5348
Sigma
Anti-Corticotropin Releasing Factor antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
| Synonym: | Anti-CRF |
| MDL number: | MFCD02096145 |
Description
| Immunogen | synthetic peptide corresponding to the C-terminal of human CRF (amino acids 25-41 with N-terminally added lysine) conjugated to KLH. |
| Specificity | The antibody does not cross-react with human or rat CRF (6-33), sheep CRF, rat urocortin, PACAP38, human ACTH, human ACTH (18-39) and sauvagine. |
| Physical form | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide. |
Properties
| antibody form | IgG fraction of antiserum |
| clone | (polyclonal) |
| form | buffered aqueous solution |
| species reactivity | pig, human, sheep, frog, rat, canine, mouse, bovine |
| application(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100 using microwave-treated sections of human placental tissue |
| microarray: suitable | |
| radioimmunoassay: 1:10,000 using 2-125I-His12-CRF, human | |
| Gene Information | human ... CRH(1392) |
| rat ... Crh(81648) | |
| mouse ... Crh(12918) | |
| shipped in | dry ice |
| storage temp. | −20°C |
Safety
| WGK Germany | 3 |
Related Products
| Array | XP725, Panorama® Antibody Microarray - XPRESS Profiler725 Kit |
References
| reference | Liu, X., et al., Fear-conditioned suppression of REM sleep: relationship to Fos expression patterns in limbic and brainstem regions in BALB/cJ mice. Brain Res. 991, 1-17, (2003) Abstract |
| Flik, G., et al., Corticotropin-releasing factor (CRF) and CRF-binding protein expression in and release from the head kidney of common carp: evolutionary conservation of the adrenal CRF system. J. Endocrinol. 193, 349-357, (2007) Abstract | |
| Zouboulis, C.C., et al., Corticotropin-releasing hormone: An autocrine hormone that promotes lipogenesis in human sebocytes Proc. Natl. Acad. Sci. U. S. A. 99, 7148-7153, (2002) Abstract |
